論文 - 詳細
| RRC ID | 6353 |
|---|---|
| 著者 | Dorsett M, Westlund B, Schedl T. |
| タイトル | METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans. |
| ジャーナル | Genetics |
| Abstract |
Germ-line stem cells are unique because they either self-renew through mitosis or, at a certain frequency, switch to meiosis and produce gametes. The switch from proliferation to meiosis is tightly regulated, and aberrations in switching result in either too little or too much proliferation. To understand the genetic basis of this regulation, we characterized loss-of-function mutations and a novel tumorous allele of Caenorhabditis elegans mett-10, which encodes a conserved putative methyltransferase. We show that METT-10 is a nuclear protein that acts in the germ line to inhibit the specification of germ-cell proliferative fate. METT-10 also promotes vulva, somatic gonad, and embryo development and ensures meiotic development of those germ cells that do differentiate. In addition, phenotypic analysis of a mett-10 null allele reveals that METT-10 enables mitotic cell cycle progression. The finding that METT-10 functions to inhibit germ-cell proliferative fate, despite promoting mitotic cell cycle progression of those germ cells that do proliferate, separates the specification of proliferative fate from its execution. |
| 巻・号 | 183(1) |
| ページ | 233-47 |
| 公開日 | 2009-9-1 |
| DOI | 10.1534/genetics.109.105270 |
| PII | genetics.109.105270 |
| PMID | 19596901 |
| PMC | PMC2746148 |
| MeSH | Alleles Amino Acid Sequence Animals Animals, Genetically Modified Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Cell Differentiation / genetics Cell Proliferation* Down-Regulation Female Germ Cells / metabolism Germ Cells / physiology* Male Methyltransferases / genetics Methyltransferases / metabolism Methyltransferases / physiology* Models, Biological Molecular Sequence Data Neoplasms / genetics Phenotype Sequence Homology, Amino Acid |
| IF | 4.015 |
| 引用数 | 15 |
| WOS 分野 | GENETICS & HEREDITY |
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オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2697 |