Reference - Detail
| RRC ID | 87304 |
|---|---|
| Author | Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, Moons L, De Groef L. |
| Title | The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. |
| Journal | Acta Neuropathol Commun |
| Abstract |
In this study, we report the results of a comprehensive phenotyping of the retina of the AppNL-G-F mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the AppNL-G-F mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the AppNL-G-F retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD. |
| Volume | 9(1) |
| Pages | 6 |
| Published | 2021-1-6 |
| DOI | 10.1186/s40478-020-01102-5 |
| PII | 10.1186/s40478-020-01102-5 |
| PMID | 33407903 |
| PMC | PMC7788955 |
| MeSH | Alzheimer Disease / genetics Alzheimer Disease / metabolism* Alzheimer Disease / pathology Alzheimer Disease / physiopathology Amyloid beta-Peptides / metabolism* Amyloid beta-Protein Precursor / genetics Animals Disease Progression Electroretinography Gliosis / metabolism Gliosis / pathology Hyperspectral Imaging Mice Mice, Transgenic Microglia / pathology Microglia / physiology Peptide Fragments / metabolism Phenotype Plaque, Amyloid / metabolism* Plaque, Amyloid / pathology Plaque, Amyloid / physiopathology Retina / metabolism* Retina / pathology Retina / physiopathology Retinal Neurons / physiology Retinal Vein / pathology Tomography, Optical Coherence |
| IF | 5.883 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC06344 |