論文 - 詳細
RRC ID | 46158 |
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著者 | Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. |
タイトル | Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. |
ジャーナル | Nat Chem Biol |
Abstract |
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. |
巻・号 | 7(12) |
ページ | 891-3 |
公開日 | 2011-11-6 |
DOI | 10.1038/nchembio.698 |
PII | nchembio.698 |
PMID | 22057127 |
MeSH | Animals Caenorhabditis elegans / drug effects* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / antagonists & inhibitors* Caenorhabditis elegans Proteins / metabolism Cytochrome P-450 Enzyme Inhibitors* Cytochrome P-450 Enzyme System / metabolism Enzyme Activation / drug effects Enzyme Inhibitors / chemistry Enzyme Inhibitors / pharmacology* Isoxazoles / chemistry Isoxazoles / pharmacology* Larva / drug effects Longevity / drug effects* Molecular Structure Piperidines / chemistry Piperidines / pharmacology* Pyridines / chemistry Pyridines / pharmacology* Stereoisomerism Structure-Activity Relationship |
IF | 12.587 |
引用数 | 16 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
線虫 | NA |