| RRC ID |
2049
|
| Author |
Honma M, Namikawa K, Mansur K, Iwata T, Mori N, Iizuka H, Kiyama H.
|
| Title |
Developmental alteration of nerve injury induced glial cell line-derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate.
|
| Journal |
J Neurochem
|
| Abstract |
Axotomy-induced neuronal death occurs in neonatal motoneurons, but not in adult rat. Here we demonstrated that during the course of postnatal development, nerve injury induced down-regulation of the glial cell line-derived neurotrophic factor (GDNF) receptor GFRalpha1 in axotomized hypoglossal motoneurons of rat are gradually converted to the adult up-regulation pattern of response. The compensatory expression of GFRalpha1 specifically in the injured motoneurons of neonates by adenovirus succeeded in rescuing the injured neurons without an application of growth factors. To the contrary, the nuclear antisense RNA for GFRalpha1 expression accelerates the axotomy-induced neuronal death in pups. These findings suggest that the receptor expression response after nerve injury is critical for the determination of injured motoneuron fate.
|
| Volume |
82(4)
|
| Pages |
961-75
|
| Published |
2002-8-1
|
| DOI |
10.1046/j.1471-4159.2002.01043.x
|
| PII |
1043
|
| PMID |
12358802
|
| MeSH |
Age Factors
Animals
Animals, Newborn
Axotomy
Brain-Derived Neurotrophic Factor / pharmacology
Cell Death / drug effects
Cell Line
Down-Regulation
Drosophila Proteins*
Gene Expression Regulation, Developmental* / drug effects
Genetic Vectors / administration & dosage
Genetic Vectors / genetics
Glial Cell Line-Derived Neurotrophic Factor
Glial Cell Line-Derived Neurotrophic Factor Receptors
Humans
Hypoglossal Nerve / growth & development
Hypoglossal Nerve / metabolism*
Hypoglossal Nerve Injuries*
Immunohistochemistry
In Situ Hybridization
Membrane Glycoproteins*
Mononeuropathies / metabolism*
Motor Neurons / cytology
Motor Neurons / drug effects
Motor Neurons / metabolism*
Nerve Growth Factors*
Nerve Tissue Proteins / pharmacology
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins / pharmacology
Proto-Oncogene Proteins c-ret
RNA, Antisense / pharmacology
RNA, Messenger / antagonists & inhibitors
RNA, Messenger / metabolism
Rats
Rats, Wistar
Receptor Protein-Tyrosine Kinases / genetics
Receptor Protein-Tyrosine Kinases / metabolism*
Receptor Protein-Tyrosine Kinases / pharmacology
Receptors, Cell Surface / genetics
Receptors, Cell Surface / metabolism
Receptors, Nerve Growth Factor*
Up-Regulation
|
| IF |
4.066
|
| Times Cited |
23
|
|
WOS Category
|
NEUROSCIENCES
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| DNA material |
pCALwL (RDB01679) |
