RRC ID 28103
Author Tsukamoto Y, Katayama C, Shinohara M, Shinohara A, Maekawa S, Miyamoto M.
Title The small GTPase Rab5 homologue Ypt5 regulates cell morphology, sexual development, ion-stress response and vacuolar formation in fission yeast.
Journal Biochem Biophys Res Commun
Abstract Inner-membrane transport is critical to cell function. Rab family GTPases play an important role in vesicle transport. In mammalian cells, Rab5 is reported to be involved in the regulation of endosome formation, phagocytosis and chromosome alignment. Here, we examined the role of the fission yeast Rab5 homologue Ypt5 using a point mutant allele. Mutant cells displayed abnormal cell morphology, mating, sporulation, endocytosis, vacuole fusion and responses to ion stress. Our data strongly suggest that fission yeast Rab5 is involved in the regulation of various types of cellular functions.
Volume 441(4)
Pages 867-72
Published 2013-11-29
DOI 10.1016/j.bbrc.2013.10.158
PII S0006-291X(13)01860-3
PMID 24211211
MeSH Endocytosis / genetics Genes, Mating Type, Fungal Membrane Fusion Point Mutation Schizosaccharomyces / cytology* Schizosaccharomyces / genetics Schizosaccharomyces / growth & development* Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism Schizosaccharomyces pombe Proteins / physiology* Spores, Fungal / cytology Spores, Fungal / genetics Spores, Fungal / growth & development Stress, Physiological / genetics Vacuoles / enzymology Vacuoles / genetics Vacuoles / physiology* rab GTP-Binding Proteins / genetics rab GTP-Binding Proteins / metabolism rab GTP-Binding Proteins / physiology*
IF 2.985
Times Cited 4
Yeast TN8 TN29