| RRC ID |
28861
|
| Author |
Hori K, Sen A, Artavanis-Tsakonas S.
|
| Title |
Genetic circuitry modulating notch signals through endosomal trafficking.
|
| Journal |
Methods Enzymol
|
| Abstract |
Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are increasingly appreciated to play a major role in controlling Notch signaling in development.
|
| Volume |
534
|
| Pages |
283-99
|
| Published |
2013-12-17
|
| DOI |
10.1016/B978-0-12-397926-1.00016-0
|
| PII |
B978-0-12-397926-1.00016-0
|
| PMID |
24359960
|
| MeSH |
Alleles
Animals
Arrestins / genetics
Arrestins / metabolism
Cells, Cultured
Drosophila Proteins / genetics
Drosophila Proteins / metabolism*
Drosophila melanogaster / genetics*
Drosophila melanogaster / growth & development
Drosophila melanogaster / metabolism
Endocytosis
Endosomes / metabolism*
Gene Expression Regulation, Developmental
Genetic Testing
Genome, Insect*
Genotype
Imaginal Discs / cytology
Imaginal Discs / metabolism
Membrane Proteins / genetics
Membrane Proteins / metabolism
Mutation
Phenotype
Protein Transport
Receptors, Notch / genetics
Receptors, Notch / metabolism*
Signal Transduction / genetics*
Ubiquitination
Wings, Animal / growth & development
Wings, Animal / metabolism
Wings, Animal / pathology
|
| IF |
1.394
|
| Times Cited |
2
|
|
WOS Category
|
BIOCHEMICAL RESEARCH METHODS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Drosophila |
|
