Reference - Detail
| RRC ID | 33362 |
|---|---|
| Author | Butler SJ, Ray S, Hiromi Y. |
| Title | klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron. |
| Journal | Development |
| Abstract |
klingon is a member of the Immunoglobulin superfamily and is expressed in a restricted pattern of neurons during embryonic neurogenesis and in the R7 photoreceptor precursor throughout its development. Starting from the H214 enhancer trap line, we identified a transcription unit, klingon, that encodes a putative protein of 528 amino acids and contains three C2-type Immunoglobulin-like domains followed by one fibronectin type III repeat. When Klingon is expressed in S2 tissue culture cells, it is associated with the cell membrane by a glycosyl-phosphatidylinositol linkage and can mediate homophilic adhesion. Genetic analysis has revealed that klingon is an essential gene that participates in the development of the R7 neuron. Ectopic expression of klingon in all neurons in a sevenless background can alter the position of the R8 rhabdomere. |
| Volume | 124(4) |
| Pages | 781-92 |
| Published | 1997-2-1 |
| DOI | 10.1242/dev.124.4.781 |
| PMID | 9043060 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cell Adhesion Cell Adhesion Molecules* Cell Aggregation Cell Differentiation Cells, Cultured Cloning, Molecular DNA Transposable Elements / genetics Drosophila / embryology Drosophila / genetics* Drosophila Proteins* Eye Proteins / chemistry Eye Proteins / genetics* Eye Proteins / physiology Gene Expression Regulation, Developmental / genetics Genes, Immunoglobulin Genes, Insect* Genotype Glycosylphosphatidylinositols / chemistry Immunohistochemistry Molecular Sequence Data Mutation Neurons / metabolism Neuropeptides / chemistry Neuropeptides / genetics* Neuropeptides / physiology Phenotype Photoreceptor Cells, Invertebrate / cytology* Photoreceptor Cells, Invertebrate / embryology Photoreceptor Cells, Invertebrate / metabolism Sequence Homology, Amino Acid |
| IF | 5.611 |
| Times Cited | 37 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |