論文 - 詳細
| RRC ID | 4259 |
|---|---|
| 著者 | Lu Q, Zhang Y, Hu T, Guo P, Li W, Wang X. |
| タイトル | C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. |
| ジャーナル | Development |
| Abstract |
During apoptosis, the dying cell activates an intrinsic mechanism that quickly dismantles itself. The apoptotic cell corpses are then recognized and removed by neighboring cells or professional phagocytes. How dying cells are degraded after internalization is poorly understood. Here, we report the identification and characterization of unc-108, the Caenorhabditis elegans homolog of the human Rab GTPase 2, as a novel component involved in the degradation of apoptotic cells. unc-108 is expressed and functions in the engulfing cells and is likely to affect the degradation rather than the internalization of cell corpses. Similar to other Rab GTPases, unc-108 also affects endocytosis, acting in the endosomal trafficking from early to late endosome and late endosome to lysosome. UNC-108 co-localizes with RAB-5, RAB-7 and LMP-1 to the phagosome and promotes cell corpse degradation, possibly by mediating phagosome maturation. |
| 巻・号 | 135(6) |
| ページ | 1069-80 |
| 公開日 | 2008-3-1 |
| DOI | 10.1242/dev.016063 |
| PII | dev.016063 |
| PMID | 18256195 |
| MeSH | Alleles Animals Animals, Genetically Modified Apoptosis / physiology* Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Egg Proteins / genetics Egg Proteins / metabolism Endocytosis / physiology Female Gene Expression Genes, Helminth Lysosomes / metabolism Membrane Glycoproteins / metabolism Mutation Phagosomes / metabolism RNA Interference rab GTP-Binding Proteins / antagonists & inhibitors rab GTP-Binding Proteins / genetics rab GTP-Binding Proteins / metabolism* rab5 GTP-Binding Proteins / metabolism rab7 GTP-Binding Proteins |
| IF | 5.611 |
| 引用数 | 45 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm469 |