論文 - 詳細
| RRC ID | 4268 |
|---|---|
| 著者 | Mukhopadhyay S, Lu Y, Shaham S, Sengupta P. |
| タイトル | Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans. |
| ジャーナル | Dev Cell |
| Abstract |
Nonmotile primary cilia are sensory organelles composed of a microtubular axoneme and a surrounding membrane sheath that houses signaling molecules. Optimal cellular function requires the precise regulation of axoneme assembly, membrane biogenesis, and signaling protein targeting and localization via as yet poorly understood mechanisms. Here, we show that sensory signaling is required to maintain the architecture of the specialized AWB olfactory neuron cilia in C. elegans. Decreased sensory signaling results in alteration of axoneme length and expansion of a membraneous structure, thereby altering the topological distribution of a subset of ciliary transmembrane signaling molecules. Signaling-regulated alteration of ciliary structures can be bypassed by modulation of intracellular cGMP or calcium levels and requires kinesin-II-driven intraflagellar transport (IFT), as well as BBS- and RAB8-related proteins. Our results suggest that compensatory mechanisms in response to altered levels of sensory activity modulate AWB cilia architecture, revealing remarkable plasticity in the regulation of cilia structure. |
| 巻・号 | 14(5) |
| ページ | 762-74 |
| 公開日 | 2008-5-1 |
| DOI | 10.1016/j.devcel.2008.03.002 |
| PII | S1534-5807(08)00104-4 |
| PMID | 18477458 |
| PMC | PMC2442577 |
| MeSH | Animals Bacteria Biological Transport Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / metabolism* Caenorhabditis elegans / ultrastructure* Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Cell Membrane / metabolism Cilia / ultrastructure* Cyclic GMP / metabolism Embryonic Development Ion Channels / metabolism Kinesins / metabolism Larva Mutation / genetics Olfactory Receptor Neurons / cytology* Olfactory Receptor Neurons / ultrastructure* Phenotype Protein Binding Signal Transduction* |
| IF | 10.092 |
| 引用数 | 79 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm324 tm2526 |