RRC ID 46290
Author Chen Z, Hendricks M, Cornils A, Maier W, Alcedo J, Zhang Y.
Title Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans.
Journal Neuron
Abstract The insulin/insulin-like peptides (ILPs) regulate key events in physiology, including neural plasticity. However, the cellular and circuit mechanisms whereby ILPs regulate learning remain largely unknown. Here, we characterize two ILPs that play antagonistic roles in aversive olfactory learning of C. elegans. We show that the ILP ins-6 acts from ASI sensory neurons to enable learning by repressing the transcription of another ILP, ins-7, specifically in URX neurons. A high level of INS-7 from URX disrupts learning by antagonizing the insulin receptor-like homolog DAF-2 in the postsynaptic neurons RIA, which play an essential role in the neural circuit underlying olfactory learning. We also show that increasing URX-generated INS-7 and loss of INS-6, both of which abolish learning, alter RIA neuronal property. Together, our results reveal an "ILP-to-ILP" pathway that links environment-sensing neurons, ASI and URX, to the key neuron, RIA, of a network that underlies olfactory plasticity and modulates its activity.
Volume 77(3)
Pages 572-85
Published 2013-2-6
DOI 10.1016/j.neuron.2012.11.025
PII S0896-6273(12)01040-9
PMID 23395381
PMC PMC3569836
MeSH Amino Acids Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning / drug effects Avoidance Learning / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Chemotaxis / drug effects Chemotaxis / physiology Choice Behavior / physiology Dose-Response Relationship, Drug Embryo, Nonmammalian Genotype Green Fluorescent Proteins / genetics Insulin / chemistry* Kaplan-Meier Estimate Mutation / genetics Odorants Olfactory Pathways / cytology Olfactory Pathways / physiology* Peptide Hormones / classification Peptide Hormones / genetics Peptide Hormones / physiology* Protein-Serine-Threonine Kinases / genetics Protein-Serine-Threonine Kinases / metabolism Receptor, Insulin / genetics Receptor, Insulin / metabolism Sensory Receptor Cells / drug effects Sensory Receptor Cells / physiology Signal Transduction / drug effects Signal Transduction / physiology* Smell / drug effects*
IF 14.319
Times Cited 28
WOS Category NEUROSCIENCES
Resource
C.elegans tm2416 tm2001 tm1907 tm2308