論文 - 詳細
| RRC ID | 46717 |
|---|---|
| 著者 | Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, Qi X, Sun J, Miao L, Yang C. |
| タイトル | Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. |
| ジャーナル | Science |
| Abstract |
The cell surface receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Here, we found that the C. elegans intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1. Retromer was recruited to the surfaces of phagosomes containing cell corpses, and its loss of function caused defective cell corpse removal. The retromer probably acted through direct interaction with CED-1 in the cell corpse recognition pathway. In the absence of retromer function, CED-1 associated with lysosomes and failed to recycle from phagosomes and cytosol to the plasma membrane. Thus, retromer is an essential mediator of apoptotic cell clearance by regulating phagocytic receptor(s) during cell corpse engulfment. |
| 巻・号 | 327(5970) |
| ページ | 1261-4 |
| 公開日 | 2010-3-5 |
| DOI | 10.1126/science.1184840 |
| PII | science.1184840 |
| PMID | 20133524 |
| MeSH | Amino Acid Sequence Animals Apoptosis* Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Membrane / metabolism Lysosomes / metabolism Membrane Proteins / metabolism* Microscopy, Electron, Transmission Molecular Sequence Data Phagocytosis* Phagosomes / metabolism* Protein Transport* RNA Interference Recombinant Fusion Proteins / metabolism Sorting Nexins Vesicular Transport Proteins / genetics Vesicular Transport Proteins / metabolism* |
| IF | 41.846 |
| 引用数 | 83 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm847 tm3790 tm1320 tm2423 tm1523 |