論文 - 詳細
| RRC ID | 6032 |
|---|---|
| 著者 | Tambe Y, Yamamoto A, Isono T, Chano T, Fukuda M, Inoue H. |
| タイトル | The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum. |
| ジャーナル | Cancer Lett |
| Abstract |
The drs gene is an apoptosis-inducing tumor suppressor. Previously, we showed that drs contributes to the suppression of tumor formation by generating drs-knockout mice. In this study, by using drs KO mouse embryonic fibroblasts, we found that drs is involved in the autophagy regulation under low serum culture conditions. Both electron microscopy and GFP-LC3 analyses demonstrated that drs is involved in the maturation process of autophagy from autophagosomes to autolysosomes. In addition, drs could associate with Rab24 and the association between drs and Rab24 was enhanced during autophagy. Drs was also co-localized with Rab24 on punctuated structures during autophagy. |
| 巻・号 | 283(1) |
| ページ | 74-83 |
| 公開日 | 2009-9-28 |
| DOI | 10.1016/j.canlet.2009.03.028 |
| PII | S0304-3835(09)00220-1 |
| PMID | 19368996 |
| MeSH | Animals Autophagy / physiology* Cell Culture Techniques Cells, Cultured DNA Fingerprinting Fibroblasts / metabolism* Fluorescent Antibody Technique Genes, Tumor Suppressor / physiology* Humans Immunoblotting Immunoprecipitation Male Membrane Proteins / genetics Membrane Proteins / metabolism* Mice Mice, Knockout Microscopy, Electron, Transmission Phagosomes / genetics Phagosomes / metabolism* Serum rab GTP-Binding Proteins / metabolism |
| IF | 7.36 |
| 引用数 | 14 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00806 |