Reference - Detail
| RRC ID | 69767 |
|---|---|
| Author | Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H. |
| Title | PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. |
| Journal | Cancer Cell |
| Volume | 39(9) |
| Pages | 1214-1226.e10 |
| Published | 2021-9-13 |
| DOI | 10.1016/j.ccell.2021.06.018 |
| PII | S1535-6108(21)00340-8 |
| PMID | 34375612 |
| MeSH | Adaptive Immunity / drug effects Animals Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Drug Resistance, Neoplasm / drug effects* HEK293 Cells HeLa Cells Humans Interferon Type I / metabolism* Mice Neoplasms / drug therapy* Neoplasms / genetics Neoplasms / metabolism Nucleoside Transport Proteins / genetics* Nucleoside Transport Proteins / metabolism* Signal Transduction / drug effects Small Molecule Libraries / administration & dosage* Small Molecule Libraries / pharmacology Tumor Escape / drug effects Xenograft Model Antitumor Assays |
| IF | 26.602 |
| Resource | |
| Human and Animal Cells | EBC-1(RCB1965) |