論文 - 詳細
| RRC ID | 76026 |
|---|---|
| 著者 | Ow MC, Nichitean AM, Hall SE. |
| タイトル | Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans. |
| ジャーナル | Elife |
| Abstract |
In animals, early-life stress can result in programmed changes in gene expression that can affect their adult phenotype. In C. elegans nematodes, starvation during the first larval stage promotes entry into a stress-resistant dauer stage until environmental conditions improve. Adults that have experienced dauer (postdauers) retain a memory of early-life starvation that results in gene expression changes and reduced fecundity. Here, we show that the endocrine pathways attributed to the regulation of somatic aging in C. elegans adults lacking a functional germline also regulate the reproductive phenotypes of postdauer adults that experienced early-life starvation. We demonstrate that postdauer adults reallocate fat to benefit progeny at the expense of the parental somatic fat reservoir and exhibit increased longevity compared to controls. Our results also show that the modification of somatic fat stores due to parental starvation memory is inherited in the F1 generation and may be the result of crosstalk between somatic and reproductive tissues mediated by the germline nuclear RNAi pathway. |
| 巻・号 | 10 |
| 公開日 | 2021-7-8 |
| DOI | 10.7554/eLife.61459 |
| PII | 61459 |
| PMID | 34236316 |
| PMC | PMC8291976 |
| MeSH | Aging / genetics Aging / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Fatty Acids / metabolism Fertility Gene Expression Regulation, Developmental Germ Cells Intracellular Signaling Peptides and Proteins / metabolism Larva / physiology Longevity Male Peptide Elongation Factors / metabolism Phenotype RNA Interference Reproduction / genetics Reproduction / physiology* Starvation |
| リソース情報 | |
| 線虫 | tm1425 tm1011 tm2182 tm1200 tm872 tm1890 tm331 tm420 |