Reference - Detail
| RRC ID | 11554 |
|---|---|
| Author | Nelson B, Nishimura S, Kanuka H, Kuranaga E, Inoue M, Hori G, Nakahara H, Miura M. |
| Title | Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. |
| Journal | Cell Death Differ |
| Abstract |
Transcriptional dysregulation as a result of sequestration of essential transcription factors into protein aggregates formed by polyglutamine (polyQ) expansions can lead to late-onset progressive neurodegeneration. DNA microarray analysis of Drosophila expressing polyQ in the compound eye over time revealed large numbers of transcriptional changes at the earliest stages of the disease including repression of the transient receptor potential calcium channels in a polyQ-induced cell death specific manner. While significant differences in expression profiles were found between the Drosophila compound eye and polyQ-sensitive neural cells, a number of possible key overlapping regulators were extracted. Among these, PDK1 was shown to act as a mediator for polyQ-toxicity, suggesting the involvement of the TOR pathway in polyQ-induced neurodegeneration. |
| Volume | 12(8) |
| Pages | 1115-23 |
| Published | 2005-8-1 |
| DOI | 10.1038/sj.cdd.4401635 |
| PII | 4401635 |
| PMID | 15861189 |
| MeSH | 3-Phosphoinositide-Dependent Protein Kinases Aging / genetics Aging / metabolism Animals Base Sequence Cells, Cultured Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Regulation / physiology Neurodegenerative Diseases / genetics* Neurodegenerative Diseases / metabolism* Neurons / metabolism Neurons / physiology Oligonucleotide Array Sequence Analysis Peptides / genetics Peptides / metabolism* Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / physiology* Plasmids / genetics Protein Kinases Protein Serine-Threonine Kinases / metabolism Reverse Transcriptase Polymerase Chain Reaction Ribosomal Protein S6 Kinases / metabolism Signal Transduction TOR Serine-Threonine Kinases Transcription, Genetic / physiology |
| IF | 10.717 |
| Times Cited | 16 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Drosophila | DGRC#200507 |