論文 - 詳細
| RRC ID | 28861 |
|---|---|
| 著者 | Hori K, Sen A, Artavanis-Tsakonas S. |
| タイトル | Genetic circuitry modulating notch signals through endosomal trafficking. |
| ジャーナル | Methods Enzymol |
| Abstract |
Genetic modifier screens offer a powerful, indeed a uniquely powerful tool for the analysis and identification of elements capable of modulating specific cellular functions in development. Here, we describe the methodology that allowed us to explore the genetic circuitry that affects a Notch mutant phenotype caused by the abnormal endosomal trafficking of the Notch receptor. Endosomal trafficking events are increasingly appreciated to play a major role in controlling Notch signaling in development. |
| 巻・号 | 534 |
| ページ | 283-99 |
| 公開日 | 2013-12-17 |
| DOI | 10.1016/B978-0-12-397926-1.00016-0 |
| PII | B978-0-12-397926-1.00016-0 |
| PMID | 24359960 |
| MeSH | Alleles Animals Arrestins / genetics Arrestins / metabolism Cells, Cultured Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Endocytosis Endosomes / metabolism* Gene Expression Regulation, Developmental Genetic Testing Genome, Insect* Genotype Imaginal Discs / cytology Imaginal Discs / metabolism Membrane Proteins / genetics Membrane Proteins / metabolism Mutation Phenotype Protein Transport Receptors, Notch / genetics Receptors, Notch / metabolism* Signal Transduction / genetics* Ubiquitination Wings, Animal / growth & development Wings, Animal / metabolism Wings, Animal / pathology |
| IF | 1.394 |
| 引用数 | 2 |
| WOS 分野 | BIOCHEMICAL RESEARCH METHODS BIOCHEMISTRY & MOLECULAR BIOLOGY |
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| 各媒体での言及数の合計 | 0 |
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