| RRC ID |
33362
|
| 著者 |
Butler SJ, Ray S, Hiromi Y.
|
| タイトル |
klingon, a novel member of the Drosophila immunoglobulin superfamily, is required for the development of the R7 photoreceptor neuron.
|
| ジャーナル |
Development
|
| Abstract |
klingon is a member of the Immunoglobulin superfamily and is expressed in a restricted pattern of neurons during embryonic neurogenesis and in the R7 photoreceptor precursor throughout its development. Starting from the H214 enhancer trap line, we identified a transcription unit, klingon, that encodes a putative protein of 528 amino acids and contains three C2-type Immunoglobulin-like domains followed by one fibronectin type III repeat. When Klingon is expressed in S2 tissue culture cells, it is associated with the cell membrane by a glycosyl-phosphatidylinositol linkage and can mediate homophilic adhesion. Genetic analysis has revealed that klingon is an essential gene that participates in the development of the R7 neuron. Ectopic expression of klingon in all neurons in a sevenless background can alter the position of the R8 rhabdomere.
|
| 巻・号 |
124(4)
|
| ページ |
781-92
|
| 公開日 |
1997-2-1
|
| DOI |
10.1242/dev.124.4.781
|
| PMID |
9043060
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Cell Adhesion
Cell Adhesion Molecules*
Cell Aggregation
Cell Differentiation
Cells, Cultured
Cloning, Molecular
DNA Transposable Elements / genetics
Drosophila / embryology
Drosophila / genetics*
Drosophila Proteins*
Eye Proteins / chemistry
Eye Proteins / genetics*
Eye Proteins / physiology
Gene Expression Regulation, Developmental / genetics
Genes, Immunoglobulin
Genes, Insect*
Genotype
Glycosylphosphatidylinositols / chemistry
Immunohistochemistry
Molecular Sequence Data
Mutation
Neurons / metabolism
Neuropeptides / chemistry
Neuropeptides / genetics*
Neuropeptides / physiology
Phenotype
Photoreceptor Cells, Invertebrate / cytology*
Photoreceptor Cells, Invertebrate / embryology
Photoreceptor Cells, Invertebrate / metabolism
Sequence Homology, Amino Acid
|
| IF |
5.611
|
| 引用数 |
37
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
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