| RRC ID |
349
|
| 著者 |
Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M, Zhong Y.
|
| タイトル |
Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Accumulation of amyloid-beta (Abeta) peptides in the brain has been suggested to be the primary event in sequential progression of Alzheimer's disease (AD). Here, we use Drosophila to examine whether expression of either the human Abeta40 or Abeta42 peptide in the Drosophila brain can induce pathological phenotypes resembling AD. The expression of Abeta42 led to the formation of diffused amyloid deposits, age-dependent learning defects, and extensive neurodegeneration. In contrast, expression of Abeta40 caused only age-dependent learning defects but did not lead to the formation of amyloid deposits or neurodegeneration. These results strongly suggest that accumulation of Abeta42 in the brain is sufficient to cause behavioral deficits and neurodegeneration. Moreover, Drosophila may serve as a model for facilitating the understanding of molecular mechanisms underlying Abeta toxicity and the discovery of novel therapeutic targets for AD.
|
| 巻・号 |
101(17)
|
| ページ |
6623-8
|
| 公開日 |
2004-4-27
|
| DOI |
10.1073/pnas.0400895101
|
| PII |
0400895101
|
| PMID |
15069204
|
| PMC |
PMC404095
|
| MeSH |
Aging / pathology
Alzheimer Disease / genetics
Alzheimer Disease / metabolism
Alzheimer Disease / pathology
Alzheimer Disease / physiopathology*
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / metabolism
Amyloid beta-Peptides / physiology*
Animals
Animals, Genetically Modified / genetics
Behavior, Animal
Brain / metabolism
Brain / pathology
Disease Models, Animal
Drosophila / genetics*
Humans
Mass Spectrometry
Peptide Fragments / genetics
Peptide Fragments / metabolism
Peptide Fragments / physiology*
|
| IF |
9.412
|
| 引用数 |
317
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ショウジョウバエ |
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