Reference - Detail
| RRC ID | 46511 |
|---|---|
| Author | Sugi T, Nishida Y, Mori I. |
| Title | Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans. |
| Journal | Nat Neurosci |
| Abstract |
Animals cope with environmental changes by altering behavioral strategy. Environmental information is generally received by sensory neurons in the neural circuit that generates behavior. However, although environmental temperature inevitably influences an animal's entire body, the mechanism of systemic temperature perception remains largely unknown. We show here that systemic temperature signaling induces a change in a memory-based behavior in C. elegans. During behavioral conditioning, non-neuronal cells as well as neuronal cells respond to cultivation temperature through a heat-shock transcription factor that drives newly identified gene expression dynamics. This systemic temperature signaling regulates thermosensory neurons non-cell-autonomously through the estrogen signaling pathway, producing thermotactic behavior. We provide a link between systemic environmental recognition and behavioral plasticity in the nervous system. |
| Volume | 14(8) |
| Pages | 984-92 |
| Published | 2011-6-26 |
| DOI | 10.1038/nn.2854 |
| PII | nn.2854 |
| PMID | 21706021 |
| MeSH | Adaptation, Physiological / genetics Adaptation, Physiological / physiology* Animals Animals, Genetically Modified Behavior, Animal / physiology Body Temperature / drug effects Body Temperature / genetics Body Temperature / physiology* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Down-Regulation / drug effects Down-Regulation / genetics Down-Regulation / physiology Estrogens / metabolism Estrogens / pharmacology Gene Expression Profiling / methods Green Fluorescent Proteins / genetics Heat-Shock Proteins / metabolism Locomotion / drug effects Locomotion / genetics Locomotion / physiology* Mutation / genetics Nerve Net / cytology Nerve Net / physiology Neurons / physiology Oligonucleotide Array Sequence Analysis / methods RNA, Messenger / metabolism Signal Transduction / drug effects Signal Transduction / genetics Signal Transduction / physiology* Temperature Thermosensing / drug effects Thermosensing / genetics Thermosensing / physiology* Time Factors Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 20.071 |
| Times Cited | 45 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| C.elegans | tm1473 tm2365 tm1797 tm2418 tm0830 tm1093 tm1770 |