RRC ID 69767
Author Gozgit JM, Vasbinder MM, Abo RP, Kunii K, Kuplast-Barr KG, Gui B, Lu AZ, Molina JR, Minissale E, Swinger KK, Wigle TJ, Blackwell DJ, Majer CR, Ren Y, Niepel M, Varsamis ZA, Nayak SP, Bamberg E, Mo JR, Church WD, Mady ASA, Song J, Utley L, Rao PE, Mitchison TJ, Kuntz KW, Richon VM, Keilhack H.
Title PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Journal Cancer Cell
Volume 39(9)
Pages 1214-1226.e10
Published 2021-9-13
DOI 10.1016/j.ccell.2021.06.018
PII S1535-6108(21)00340-8
PMID 34375612
MeSH Adaptive Immunity / drug effects Animals Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Drug Resistance, Neoplasm / drug effects* HEK293 Cells HeLa Cells Humans Interferon Type I / metabolism* Mice Neoplasms / drug therapy* Neoplasms / genetics Neoplasms / metabolism Nucleoside Transport Proteins / genetics* Nucleoside Transport Proteins / metabolism* Signal Transduction / drug effects Small Molecule Libraries / administration & dosage* Small Molecule Libraries / pharmacology Tumor Escape / drug effects Xenograft Model Antitumor Assays
IF 26.602
Human and Animal Cells EBC-1(RCB1965)